Among the limited existing studies, it was reported that in situ hybridization of IAPP RNA in rat islets was strikingly decreased after 12 days of insulin-induced hypoglycemia.25 Another study indicated that circulating IAPP was suppressed during insulin-induced hypoglycemia in nondiabetic human subjects.26 Furthermore, other previous studies have shown that IAPP-mediated regulation of gastric emptying,27 and food intake,28 are reduced under hypoglycemic conditions in rat models. The gene discussed is INS; the disease is Hypoglycemia.