CHRNA2 and obesity due to melanocortin 4 receptor deficiency: Consistent with this observation, publicly available human transcriptomic data revealed that CHRNA2 was readily detectable in healthy livers and that individuals with obesity or type 2 diabetes, which commonly appear with MASH as its risk factors and comorbidities, tended to have higher hepatic CHRNA2 expression than healthy control subjects (S1D–S1F Fig).