Of the 71 genes that compose the Leishmaniasis pathway, 15 DEGs downregulated (CYBA, CYBB, HLA-DRA, IFNGR1, IFNGR2, ITGAM, MYD88, NCF1, NCF4, NFKB1, NFKBIA, PTPN6, RELA, TLR2, and TLR4) (log2FC≤-0.58; FDR≤0.05) are lncRNA and/or miRNA targets, and 4 (C3, NFKBIB, STAT1, and TAB2) downregulated (p-value≤0.05) are miRNA targets, after in vitro infection of neutrophils by L. infantum. This evidence concerns the gene C3 and leishmaniasis.