Both conditions showed striking changes in genes involved in immunity and inflammation, extracellular matrix organization and focal adhesion, oxidase activity and endocytosis, axonal guidance and structure, cell cycle and growth, autophagy, cell death and mitochondrial function, providing further evidence of the possible role for the dysregulation of the circadian clock in PD related mechanisms of neurodegeneration. The gene discussed is CLOCK; the disease is Parkinson disease.