The clock gene PER3 was identified as a rare variant in human myopia [49] (Table 6) and was found in the choroid during myopia progression at ZT12 (S3B Table); PER3 is involved in sleep regulation, non-visual responses to light and a variety of circadian responses [110], supporting potential roles for light and circadian biology in myopia. The gene discussed is PER3; the disease is myopia.