The VIP gene conforms with the long-imputed role of VIP peptide in myopia; but the downregulation of VIP in progressing chick form deprivation myopia here and in chick myopia following the wearing of a minus spectacle lens (i.e., lens-induced myopia) [54] contrasts with its upregulation in primate and guinea pig myopia [55, 56], perhaps representing a species difference. This evidence concerns the gene VIP and myopia.