To highlight a few besides transcription factors, SPR participates in the biosynthesis of tetrahydrobiopterin, a cofactor for tyrosine hydroxylase and tryptophan hydroxylase that have roles in dopamine and serotonin synthesis as well as functioning as an antioxidant [71]; dopamine and serotonin have each been implicated in myopia pathogenesis [72–74]. This evidence concerns the gene TH and myopia.