Placental mRNA expression was examined for the 8 genes enriched in isolated trophoblast side-population cells (CXLC8/IL8, ELL2, GATA6, HK2, HLA-DPB1, INTS6, SERPINE3, UPP1) in placentas obtained from participants with early onset preeclampsia (n = 78) or fetal growth restriction (n = 30). This evidence concerns the gene SERPINE3 and fetal growth restriction.