Although the Echo findings in this thalassemia cohort did not show a statistically significant correlation with circulating FABP4 concentration, the estimated FABP4 exclusionary cut-off value (> 2.30 ng/ml) was able to predict various cardiac dysfunctions in thalassemia patients, including congestive heart failure (CHF), arrhythmias, tricuspid regurgitation (TR), pulmonary and systemic hypertension, and a history of thrombosis. This evidence concerns the gene FABP4 and cardiac arrhythmia.