GLP1R and Hypoglycemia: 2018). From the point of view of adverse reactions, these drugs, based on their different mechanisms of action, can cause unique side effects. For example, sulfonylureas and insulin medications may induce hypoglycemia (Unger 2012), GLP-1 receptor agonists can cause gastrointestinal reactions (Shetty et al. 2022), and SGLT-2 inhibitors are associated with urinary or reproductive system infections (Shi et al. 2022).