INS and type 2 diabetes mellitus: The level of FBG in T2DM rats was significantly reduced by Hawthorn extract at high, middle, and low doses (p < 0.01 and p < 0.05).Serum insulin levels were increase by 206.76 ± 3.76, 204.05 ± 15.17 and 176.82 ± 1.45 pg mL-1, compared to the T2DM group respectively. (p < 0.01).