To test these possibilities, we treated human neuroblastoma SH-SY5Y, rat pheochromocytoma PC12, and human neural progenitor cells (ReNcell VM) with recombinant human Aβ42 or p3 17–42 peptides at 1 μM or 2.5 μM final concentrations, and analyzed the levels of endogenous APP-CTFs and full-length APP (APP-FL) by western blotting (Figure 3A–C). This evidence concerns the gene APP and neuroblastoma.