Indeed CRP and SAA have long been recognized to be higher in people with T2D.128 More recently, a collaborative analysis of three randomized clinical trials by Ridker et al.129 investigated the association between cardiovascular events and death with each of low-density lipoprotein (LDL)-cholesterol and hs-CRP, in people in whom LDL-cholesterol had been intensively lowered, achieving contemporary standards. This evidence concerns the gene CRP and type 2 diabetes mellitus.