APP and Cognitive impairment: Some commonly deployed models for studying AD which are well-characterized for inducing neuropathological features and cognitive deficits characteristic of the disease include the mutant amyloid precursor protein and presenilin 1 (APP/PS1), Tg2576, and 5xFAD lines (Gotz et al., 2018; Sanchez-Varo et al., 2022).