In summary, the diagnostic criteria for GHIS involve the assessment of multiple parameters related to GH and IGF-1 activity in the body, including measurements of height, GH and IGF-1 levels, Insulin-like growth factor binding protein 3 (IGFBP-3) levels, and GH binding. In our case, the criteria for identifying GHIS included height below the third percentile, a basal GH level greater than 2.5 μg/L, a basal IGF level below 50 μg/L, and an IGF-1 generation test indicating levels below 15 μg/L, with prepubertal stage of development. Here, GH1 is linked to growth hormone insensitivity syndrome.