MAPK4 and ocular melanoma: Moreover, we also found many DEGs between YM × YF versus OM × YF, that were involved in various cellular processes, such as protein synthesis and regulation, signaling by Hh, MAPK6/MAPK4 signaling (aka ERK3/ERK4), regulation of PTEN stability, and regulation of RAS by GAPs, majority of which were upregulated offspring from OM × YF (Tables 1 and S2).