In Fujiwara criteria, univariate logistic analysis showed that albumin ≤35 (albumin >35 versus albumin ≤35, OR = 0.43, 95% CI: 0.21–0.86, p = 0.002), tumor size >3.0 cm (OR = 2.79, 95% CI: 1.32–5.88, p = 0.01), lymph metastasis (OR = 3.70, 95% CI: 1.76–7.77, p < 0.001) and advanced TNM stage (OR = 2.79, 95% CI: 1.32–5.88, p = 0.01) were related risk factors of postoperative complications in PC patients. The gene discussed is ALB; the disease is pachyonychia congenita.