There was no discrepancy between sarcopenia group and non-sarcopenia group in age, gender, BMI, ASA, history of diabetes, smoking, cardiovascular disease, leukocytes, neutrophils, lymphocytes, platelets, hemoglobin, NLR, CA199, PBD, albumin, creatinine, total bilirubin, direct bilirubin, operation time, tumor size, surgery method (158 open pancreaticoduodenectomy, OPD and 4 laparoscopic pancreaticoduodenectomy, LPD), TNM stage, lymph node metastasis, vascular invasion and postoperative chemotherapy (p > 0.05). The gene discussed is ALB; the disease is neoplasm.