CDKN1C and Metaphyseal dysplasia: In considering the cause of acquired autoimmunity, genetics may once again prove a link between these conditions; CDKN1C, a cell cycle regulator, is a paternally imprinted gene involved in regulating β-cell proliferation and is known to be associated with growth disorders, including BWS and IMAGe (intrauterine growth restriction [IUGR], metaphyseal dysplasia, adrenal hypoplasia congenita, and genitourinary abnormalities) syndrome [11].