Current studies have confirmed that Nesfatin-1 can improve diabetic cardiomyopathy [15], diabetic nephropathy [16], diabetic retinopathy [17], diabetic polycystic ovary syndrome [18,19] and other diseases, which is considered as one of the important potential target drugs for the treatment of diabetes-related complications [20](Prinz and Stengel, 2016).However, there have been no reports on whether Nesfatin-1 can improve Type 2 Diabetes Mellitus Erectile Dysfunction (T2DMED) and its specific mechanism. Here, NUCB2 is linked to diabetes mellitus.