The expression of NUDT11 was most positively correlated with the expression of four feature genes, including AK5, CARTPT, COPG2IT1, and NPTX2 in patients with AD, with correlation coefficients of 0.69, 0.48, 0.77, and 0.5, respectively (Fig. 8B–E). Here, AK5 is linked to Alzheimer disease.