The expression of NUDT11 was most positively correlated with the expression of four feature genes, including AK5, CARTPT, COPG2IT1, and NPTX2 in patients with AD, with correlation coefficients of 0.69, 0.48, 0.77, and 0.5, respectively (Fig. 8B–E). The gene discussed is NPTX2; the disease is Alzheimer disease.