Among them, 15 m7G regulator genes exhibited marked differential expression in brain tissues, with six of them (CYFIP1, LSM1, NCBP2, NUDT16, NUDT3, and QKI) being upregulated in patients with AD, and nine of them (DCPS, LARP1, METTL1, NUDT10, EIF4E, EIF4E2, EIF4E3, NUDT11, and SNUPN) were downregulated compared to nonAD samples. The gene discussed is LSM1; the disease is Alzheimer disease.