The expression of lncRNA Neat1 in neuronal cells of mice with sepsis is increased, it interacts directly with the hemoglobin subunit β (Hbb) to mediate the expression of PSD-95, regulating dendritic spine density associated with cognition and learning, Neat1 and Hbb may be potential diagnostic targets and therapeutic strategies for SAE [75]. The gene discussed is HBB; the disease is Sepsis.