Of note, a similar screening approach has been developed to detect the TSC-associated condition lymphangioleiomyomatosis (LAM),34,35,36,37,38,39,40 with vascular endothelial growth factor-D (VEGF-D) being identified as a circulating biomarker that can be used toward LAM diagnosis.39 This evidence concerns the gene VEGFD and lymphangioleiomyomatosis.