RARG and Miyoshi myopathy: Mechanistically, ATRA mainly activated the retinoic acid receptor (RAR)γ and interferon-β response pathways to upregulate the expression of IRF1, which initiated the transcription of OAS1, which synthesized 2–5A upon binding to carfilzomib-induced double-stranded RNA and led to degradation of the cellular RNA by RNase L and cell death, and the selective RARγ agonist BMS961 could also re-sensitize MM cells to carfilzomib in vitro (Wang Q. et al., 2022).