RARA and acute promyelocytic leukemia: APL accounts for approximately 10%–15% of all AML and is characterized by leukocyte abnormalities, anemia, low platelets, coagulation abnormalities, and severe bleeding, with a major chromosomal abnormality of t (15; 17) (q22; q12-21), which produces the PML-RARα fusion gene (Yilmaz et al., 2021).