FLT3 and acute myeloid leukemia: Low dose midostaurin (0.25–0.5 μM) + ATRA induced cell differentiation, whereas high dose midostaurin (0.25–0.5 μM) + ATRA led to apoptosis in FMS-like tyrosine kinase-3 (FLT3) AML cell line, and apoptosis induced by high dose midostaurin + ATRA was dependent on caspase-3/7.