ATRA inhibits translation and protein synthesis in AML cells, and the genes regulated by ATRA are mainly concentrated in the PI3K/AKT signaling pathway, and ATRA + PI3K/AKT inhibitor induces a large number of apoptotic cells and greatly inhibits cloning of AML cells (Wang K. et al., 2022). The gene discussed is AKT1; the disease is acute myeloid leukemia.