RARA and leukemia: It is well known that APL used to be an acute myeloid leukemia (AML) with a great risk of bleeding and a high mortality rate, and that APL is caused by a balanced translocation t (15; 17) (q22; q12-21), that leads to a fusion of the promyelocytic leukemia (PML) gene with the retinoic acid receptor alpha (RARα) gene, and that the PML-RARα fusion oncoprotein induces leukemia by blocking normal myeloid cell differentiation (Yilmaz et al., 2021).