Comparing FAERS and JADER, the SOC signals of Leu (FAERS) were more prominent in reproductive system disorders (aROR 5.28, 95% CI 5.07–5.30), product issues (aROR 4.32, 95% CI 4.24–4.41), vascular disorders (aROR 2.83, 95% CI 2.77–2.89), and renal/urinary disorders (aROR 1.05, 95% CI 1.02–1.09). The gene discussed is UBXN11; the disease is vascular disorder.