In addition, we tested and calculated the power values of the results of the MR analyses, in which the causal effect of cathepsin E on IS and MI, the effect of cathepsin L2 on the causality of CHF and the effect of cathepsin O on the causality of IS were less than 80%, and we have a cautious recommendation for the final test results. The gene discussed is CTSV; the disease is congestive heart failure.