S100B and Dravet syndrome: Although the immunocytochemical distribution of S100B in neural cell types in DS does not differ from that in control brains (Michetti et al., 1990), its expression at mRNA and protein levels and the number of S100B-immunoreactive astrocytes are markedly higher in DS brains (Jrgensen et al., 1990; Goodison et al., 1993; Chen et al., 2014).