Additionally, patients with NAFLD have higher levels of PEDF (Yilmaz et al.2011), which contributes to the non-invasive diagnosis (Yang et al.2015), and the excessive PEDF leads to an elevated susceptibility to intestinal inflammation, which, together with the raised PEDF in patients with IBD during the acute phase, hints at the potential role as a biomarker linking CLD and acute IBD correlation. Here, SERPINF1 is linked to inflammatory bowel disease.