SERPINF1 and colitis: In the research, given that diverse polypeptides of PEDF show different biofunctions (Kim et al.2024), the researchers found that 34-mer could serve as the active fragment of PEDF to exacerbate colitis, which on the one hand, the peptide could not completely replace the PEDF protein due to its instability, while on the other hand, it also offers a certain enlightenment for the more studies of PEDF polypeptides as well as the development of highly potent drugs.