For instance, salivary levels of tumor necrosis factor α (TNF-α), IL-1, IL-4, IL-6, and IL-8 have been described as relevant biomarkers for oral lichen planus diagnosis and prognosis.8 Also, IL-1β, TNF-α, IL-6, and the receptor activator of nuclear factor κB ligand (RANKL), among other cytokines, are known to be involved in immune response regulation in periodontal diseases.9 This evidence concerns the gene TNF and periodontal disorder.