Histologic examination of the biopsy specimen showed PMME, which was confirmed by comprehensive molecular genetic testing to distinguish between primary and metastatic cancer which was positive for melanoma-associated antigen recognized by T Cells (MART-1) (same as Melan-A) and negative for Pankeratin AE1/AE3, CK 7, CK 20, CK 5/6, p53, MOC-31, TTF-1, CDX-2, BRAF, KIT, and NRAS (Figures 3–5). This evidence concerns the gene MLANA and metastatic malignant neoplasm.