The MART-1 and HMB-45 are the most specific antibodies available to differentiate melanomas from other mucosal tumors; hence, the presence of MART-1 on the immunohistochemical panel of our patient confirmed the diagnosis of malignant melanoma.12 This helped rule out other neoplasms, including Kaposi sarcoma, esophageal lymphoma, and carcinoma. This evidence concerns the gene PMEL and esophagus lymphoma.