The MART-1 and HMB-45 are the most specific antibodies available to differentiate melanomas from other mucosal tumors; hence, the presence of MART-1 on the immunohistochemical panel of our patient confirmed the diagnosis of malignant melanoma.12 This helped rule out other neoplasms, including Kaposi sarcoma, esophageal lymphoma, and carcinoma. The gene discussed is PMEL; the disease is melanoma.