Nine lncRNA/miR-545-3p/PCG axes promote cancer progression, including AFAP1-AS1/miR-545-3p/HDGF6 and FAM83H-AS1/miR-545-3p/HS6ST238 in LC; CASC9/miR-545-3p/LAMC2 in oral squamous cell carcinoma (OSCC)39; SBF2-AS1/miR-545-3p/EMS1 in GC40; HOTAIR/miR-545-3p/EGFR17 and MCM3AP-AS1/miR-545-3p/CDK412 in CRC; AFAP1-AS1/miR-545-3p/VEGFA in EC41; AFAP1-AS1/miR-545-3p/CDK4 in triple-negative breast cancer (TNBC),13 and AFAP1-AS1/miR-545-3p/GNB1 in retinoblastoma (RB).42 The gene discussed is CDK4; the disease is cancer.