Among these, we have identified a cohort of TFs, namely GATA2, GATA3, FOXC1, TP53, STAT3, STAT1, CEBPB, ELK4, and REL, that demonstrate associations with diverse respiratory and kidney ailments such as COVID-19, asthma, and chronic kidney injury (Yu et al., 2017; Estrela et al., 2021; Fang et al., 2022; Yang et al., 2023; Zhang et al., 2023). This evidence concerns the gene REL and asthma.