Analysis of different hereditary models allowed to reveallinks between polymorphic variants of the CAT (rs1001179)gene with the risk of luminal B Her2-negative BC development in elder patients (60–74 years) in the log-additive model(OR = 1.87; CI 95 %: 1.22–2,85; Padj = 0.0024). This evidence concerns the gene CAT and breast cancer.