Analysis of different hereditary models with correctionfor age allowed to detect association between the risk of luminalB Her2-negative BC development and XPD (rs13181)and APEX1 (rs1130409) in the log-additive model, and CAT(rs1001179) in the dominant model (OR = 1.41; CI 95 %:1.08–1.85; Padj = 0.011; OR = 1.39; CI 95 %: 1.07–1.81;Padj = 0.013 and OR = 1.70; CI 95 %: 1.19–2.43; Padj = 0.004respectively). The gene discussed is ERCC2; the disease is breast cancer.