In primary lymphedema, we found an increase in the frequencyof the MMP2-1306C allelic variant of the gene andthe homozygous CC variant in a single genotype and in other10 out of 17 combined genetic traits, the frequency of whichis higher in this form of the disease with an obvious geneticpredisposition (Poveshchenko et al., 2010; Shevchenko etal., 2020). The gene discussed is MMP2; the disease is primary lymphedema.