Thus, thefrequency of a combined genetic trait represented by a combinationof homozygous VEGF+936 CC: MMP3-1171 5A5A:MMP9-1562 CC among the patients with secondary lymphedema exceeds the frequency of a similar indicator in the controlgroup by more than 3 times (OR = 3.37; p = 0.0110). This evidence concerns the gene VEGFA and lymphedema.