Thus, in primary lymphedema, the most significant correlationsare revealed between MMP2 and the tissue inhibitorTIMP2 levels (OR = 0.703; p < 0.01), whereas the VEGF serumlevel is inversely correlated with the MMP3 serum level(OR = –0.629; p < 0.05). The gene discussed is MMP2; the disease is primary lymphedema.