In contrast to these data,in the group of patients with secondary lymphedema, there arecompletely no combined genetic signs represented by combinationsNRP2 13581 TT: NRP2 92646 GG: KDR 14011 TC;MMP2-1306 CC: MMP3-1171 6A6A: NRP2 13581 TT: NRP292646 GG; MMP2-1306CC: NRP2 13581 TT: NRP2 92646GG: KDR 14011 TC; MMP3-1171 6A6A: MMP9-1562 CC:NRP2 13581 TT: NRP2 92646 GG and a number of others.The significance level of the differences is 0.0003–0.005. The gene discussed is NRP2; the disease is lymphedema.