Among patients with both primary and secondary lymphedema,there are significant deviations from the normativeindicators established for the control group of healthy individualsin the frequency of distribution of a number ofcomplex genotypes of the MMP 2, 3, 9 and VEGF genes,which indicates a significant influence of the studied fragmentof the patient’s genotype on predisposition to these types oflymphatic edematous syndrome. Here, VEGFA is linked to lymphedema.