At the sametime, such combinations of genotypes as VEGF-2578 CA:VEGF+936 TT: MMP9-1562 CT and VEGF-2578 CA:VEGF+936 TT: MMP2-1306 CC: MMP9-1562 CT were notfound among representatives of the group of healthy individualsand were identified exclusively among patients withprimary lymphedema. Here, MMP2 is linked to lymphedema.