When evaluating the results, attention is drawn to the presenceof combined genetic signs in both groups of patients,which alternatively are not detected in the compared samples.Thus, in the group with primary lymphedema, TIMP1-536 CC: NRP2 13581 GT: KDR 14011 TC and VEGF+936 CC:TIMP1-536 CC: NRP2 13581 GT: KDR 14011 TC are completelyabsent. Here, TIMP1 is linked to primary lymphedema.