BDNF and Alzheimer disease: Thedecrease in BDNF mRNA and protein levels in the cerebralcortex and hippocampus was shown in AD (Hock et al., 2000).BDNF-induced neuronal growth and development are mediatedby its receptors, tyrosine kinase receptor B (TrkB) andcommon neurotrophin receptor p75 (p75NTR), which bind withBDNF and proBDNF, respectively.