Integrated bioinformatics analysis identified 10 key genes, namely CDKN1A, CELSR2, NME5, SURF4, PSMA5, TSC1, RPL7A, SURF6, PRDX3, and FTO, which could help elucidate the potential mechanisms underlying the association between CHF and structural alterations in the cerebral cortex. Here, CELSR2 is linked to congestive heart failure.