Integrated bioinformatics analysis identified 10 key genes, namely CDKN1A, CELSR2, NME5, SURF4, PSMA5, TSC1, RPL7A, SURF6, PRDX3, and FTO, which could help elucidate the potential mechanisms underlying the association between CHF and structural alterations in the cerebral cortex. This evidence concerns the gene NME5 and congestive heart failure.