30–50% patientsInsomniaSleeping accompanied by talking, yelling, swearing, scratching, hitting, kicking, jumping, and other dramatic, forceful, and potentially injurious movements (RBD) (Gjerstad et al., 2007).Excessive daytime sleepiness (EDS) (Leite Silva et al., 2023)Restless Legs Syndrome (RLS) (Leite Silva et al., 2023)Possibly related to a decrease in hypocretin (orexin) neurons (Fronczek et al., 2007) (Thannickal et al., 2007). The gene discussed is HCRT; the disease is Ehlers-Danlos syndrome.