PRKN and Parkinson disease: Mutations in 11 genes associated with PD (SNCA, PINK1, PRKN, DJ1, ATP13A2, PLA2G6, FBXO7, LRRK2, CHCHD2, VPS35, and VPS13C) influence mitochondrial energy generation, reactive oxygen species production, mitochondrial biogenesis, and quality control, according to genetic research (Li et al., 2021).