SNCA and Parkinson disease: Notably, with the discovery and studies of PD-related pathogenic genes (Blauwendraat et al., 2020), i.e., SNCA, PARKIN, PINK1, LRRK2, and DJ-1..., it has been revealed that oxidative stress (OS) is considered a key modulator in the occurrence and development of PD (Maiti et al., 2017).