KLK3 and posterior cortical atrophy: In our study, we evaluated whether the prostate CB can find more PCa and csPCa compared with TRUSB and developed a multivariable model based on the mpMRI-based scores and clinical parameters to provide a reference for clinicians in forecasting biopsy outcomes in biopsy-naïve patients with PSA 4~20 ng/ml and making a more comprehensive assessment during the decision-making of the prostate biopsy.