MNX1-AS1 regulates miR-744-5p (165) or the PPFIA4/AKT/HIF-1α axis (166), playing a critical role in the invasion and migration of CRC cells.NEAT1 promotes the expression of ZEB1 by targeting miR-448 (167), or enhances the proliferation and invasion of CRC through the miR-216b/YY1 axis (168). The gene discussed is HIF1A; the disease is colorectal carcinoma.