PVT1 promotes CRC proliferation through a variety of regulatory pathways, these pathways include the PVT1/miR-24-3p/NRP1 axis, PVT1/miR-1207-5p/Wnt6/β-catenin axis,PVT1/miR-761/MAPK1 axis and PVT1/miR-30d-5p/RUNX2 axis (179–182). This evidence concerns the gene MAPK1 and colorectal carcinoma.