Knockdown of TUG1 not only inhibits CRC migration and invasion through the miR-542-3p/TRIB2 axis (198) but also, by overexpressing it, regulates the miR-26a-5p/MMP14/p38 MAPK/Hsp27 axis in vitro and in vivo to accelerate cancer invasion (199). The gene discussed is TRIB2; the disease is colorectal carcinoma.