There was a significantly increased expression of NLRP3 inflammasome in the epithelium of pooled SJS/TEN patients (average IF intensity of 1958.163 um^2) compared to the epithelium of pooled LP patients (average IF intensity of 1547.783 um^2) and the epithelium of normal control patients (average IF intensity of 1496.824 um^2) (p<0.0001) (Figure 1A, 1B). Here, NLRP3 is linked to toxic epidermal necrolysis.