ATG5 and tuberculosis: For example, in the case of murine models of Mycobacterium tuberculosis infection, atg8ylation machinery protects against tuberculosis pathogenesis but Atg5 knockout has a particularly strong phenotype exceeding other atg8ylation genes, sugestiong that ATG5 possesses atg8ylation (mATG8s lipid conjugation) independent functions 35,46,53–56.