FKBP4 and Alzheimer disease: While studies observed decreased expression of non-mitophagy-related FKBPs in AD brains such as FKBP12 and FKBP52 [22, 23], the role of FKBP8 in AD remains unclear, and the impact of pTau on FKBP8-mediated mitophagy is unexplored.