TARDBP and amyotrophic lateral sclerosis: The dysregulation of the RNA binding protein (RBP), TAR DNA-binding protein 43 (TDP-43) is a hallmark pathobiology observed in ~97% of all ALS patients that (Arai et al., 2006; Neumann et al., 2006) ~45% of Frontotemporal lobar degeneration (FTLD) patients (S. C. Ling et al., 2013; Neumann et al., 2006), and 40%−60% of Limbic Associated TDP-43 Encephalopathy (LATE) patients (McKee et al., 2010; Nelson et al., 2019; Tremblay et al., 2011).