SPTLC2 and hereditary sensory and autonomic neuropathy type 1: While studying hereditary sensory and autonomic neuropathy type I (HSAN-I), one group found that serine palmitoyltransferase long chain base subunit 2 (SPTLC2) dysfunction results in increased mTORC1 activation and ER stress, specifically XBP1s and CHOP upregulation, thus resulting in CD8+ T cell apoptosis (135).