High expression of WRC components have been associated with various types of cancers including breast (WAVE2, WAVE3, ABI1, NAP1), ovarian (WAVE1, ABI1), prostate (WAVE1, WAVE3, ABI1), colorectal (WAVE2, WAVE3), liver (WAVE2, WAVE3), and lung (WAVE2) and are associated with tumor invasiveness and poor prognosis [see (119) for review]. The gene discussed is WASF1; the disease is cancer.