generated and analyzed Hem1-/- (Nckap1ltm1.1Iri) and Hem1fl/flLysMCre mice and found that Hem-1 deficiency resulted in the accumulation of excessive mucus and cell debris in the airways, leading to pulmonary alveolar proteinosis. This evidence concerns the gene NCKAP1L and Intraalveolar phospholipid accumulation.