In 434 patients from the pooled cohort of Ruijin Cohort 1 and Ruijin Cohort 2 with early TNBC, BRCA tumor mutation was associated with menopausal status (mutation rate 18.32% in premenopausal women versus 10.78% in postmenopausal women, P = 0.035), family history of breast/ovarian cancer (mutation rate 23.81% in women with family history versus 12.67% in women without family history, P = 0.016) and high Ki-67 levels (mutation rate 16.97% in high Ki-67 group versus 5.77% in low Ki-67 group, P = 0.005). Here, MKI67 is linked to neoplasm.