CD79A and neoplasm: Notably, investigations into renal cell carcinoma indicated that in tumors harboring dense TLS and PCs, PCs were predominantly distributed around the B-cell follicles, synthesizing IgG or IgA antibodies capable of binding to tumor cells, indicating that PCs in the tumor can produce anti-tumor antibodies in situ (57), corroborating findings from studies on soft tissue sarcoma and NSCLC (58, 89, 95).