IFNG and neoplasm: Moreover, the maturation of TLS could be influenced by TDLNs, where diminished IFN-γ signaling from B cells and natural killer (NK) cells leads to reduced infiltration of memory B-cell populations in the TDLNs and subsequently hampers the transportation of B cells from TDLNs to the primary tumor site, thus impeding TLS maturation within the tumor (86).