CD8A and neoplasm: Analogous findings emerged from a study of human papillomavirus (HPV)+ oropharyngeal squamous cell carcinoma, revealing a positive correlation between the density of CD20+ TIL-B interacting with CD8+ tumor-infiltrating lymphocytes (TILs) and the infiltration frequency of HPV-specific CD8+ T cells (104); the density of B-/T-cell interactions was further associated with a favorable prognosis for immunotherapy, with B-cell exhaustion following anti-CD20 immunotherapy resulting in diminished tumor infiltration by macrophages and CD8+ T cells (105).