In LOPE patients, serum TUG1 was negatively correlated with the extent of albuminuria (r = − 0.386, P = 0.006) and the presence of low AF (r = −0.346, P = 0.014) and its correlations with IUGR and FBW (r = 0.48, P = 0.0004) were intensified. This evidence concerns the gene TUG1 and fetal growth restriction.