Both anchorage-dependent GBM cells and neurospheres exhibited a constant increase in NRF2 expression at both the transcriptional and protein levels upon CPZ treatment (Fig. 2A and B, respectively); in contrast, under the same conditions, RPE-1 non-cancer cells showed no significant modulation in NRF2 mRNA or protein expression. Here, NFE2L2 is linked to glioblastoma.