MGMT and glioma: An efficient DNA repair system and/or elevated MGMT protein levels characteristic as observed in GBM patients carrying a hypo- or unmethylated MGMT gene, confer resistance towards both radiotherapy and TMZ [5], allowing GBM cell to evade treatment, thus increasing the likelihood of clinical relapse [4, 6, 7], circumstances in which glioma stem cells (GSC) play a key role [8, 9].