GJA1 and glioblastoma: As illustrated in our schematic diagram (Fig. 9), TMZ treatment triggers an escalation in DDR and upregulation of Cx43 expression, thus our model suggests that combining CPZ and TMZ treatments could induce a decrease in DDR and Cx43 expression, prompting an anticipated cell cycle progression, which ultimately culminates in mitotic catastrophe and cell death for GBM cells.