Our experimental analysis of this DNA repair gene set revealed that: (a) treating GBM cells with TMZ elevates DNA repair genes expression; (b) treating GBM cells with CPZ diminishes DNA repair genes expression; (c) silencing Cx43 in GBM cells leads to a decrease in DNA repair gene expression, particularly in GSCs, the most treatment-resistant GBM cells. Here, GJA1 is linked to glioblastoma.