Scientific evidence has shown that the levels of TNF-α, IL-6, and IL-8 are altered in the saliva of subjects with different oral pathologies such as DC, oral lichen planus, periodontitis, peri-implantitis, primary Sjögren’s syndrome, oral leukoplakia, and drug-related osteonecrosis of the jaw, among others [11]. The gene discussed is TNF; the disease is dyskeratosis congenita.