This analysis involved a multivariable-adjusted Cox proportional hazards model adjusted for age, sex, smoking status, drinking history, regular physical activity, income, BMI, histories of hypertension, chronic kidney disease, congestive heart failure, fasting glucose, HDL-C and LDL-C levels, eGFR, diabetes duration, the number of medications used to treat diabetes, and the simultaneous use of insulin. The gene discussed is INS; the disease is chronic kidney disease.