In pulmonary fibrosis models, following stimulation by TGF-β1, Brd4 occupies the promoters of interleukin-6 (IL-6), α-smooth muscle actin (α-SMA), and plasminogen activator inhibitor-1 (PAI-1), thereby promoting fibrosis [69]. This evidence concerns the gene TGFB1 and pulmonary fibrosis.