In this large prospective cohort study involving the general population, we found, for the first time, that extremely high levels of both Lp(a) and FIB together conferred a 1.8-fold risk of all-cause mortality, a 2.1-fold risk of CVD-related mortality, and a 2.4-fold risk of cancer-related mortality, suggesting that individuals with both Lp(a) and FIB at higher levels may have a higher risk of mortality. This evidence concerns the gene LPA and cancer.